Analysis of the state of medicine in Pakistan: challenges and future prospects
DOI:
https://doi.org/10.57125/FEM.2022.06.30.05Keywords:
medication quality, PRISMA, systematic review, good manufacturing practicesAbstract
Aims: This article examines the condition of medicine in Pakistan utilising existing scientific articles, reports, and other published information in order to describe the position of the country regarding medication quality and the presence of deprived and/or false pharmaceutical preparations.
Methodology: In this study, studies concerned with the condition of medicine in Pakistan have been systematically searched. The most sustainable recent studies on the condition of medicine in Pakistan in PubMed, Medline, the Cochrane library, EmBase, and Google Scholar were evaluated for this systematic review. The search criteria were [Medicine or drug] AND [analysis] AND [Pakistan]. To guarantee the caliber and consistency of the selected articles, many criteria were utilised for article eligibility, in accordance with the PRISMA principles and critical assessment tools.
Results: The authors first retrieved 750 papers for use in electronic databases. These publications were then once again compared to the study's goals, and any that didn't fit the bill were disregarded. After further screening 40 publications were chosen and dispersed to the authors for additional evaluations. The authors' detailed brainstorming session resulted in the inclusion of 18 pertinent papers in the review.
Scientific Novelty: This is the first systematic review performed in Pakistan in order to highlight the state of medicine.
Conclusion: The research suggests that to effectively regulate substandard and counterfeit medication in Pakistan, regulatory procedures for facility inspections and Good Manufacturing Practices (GMP) assessments, analytical laboratories, and capacity building, all need to be strengthened. The material that is currently available cannot support the claim that 40–50% of Pakistan's medications are of low quality. The primary causes of the subpar services provided by community pharmacies include a lack of competent personnel, a lack of advice, and a lack of professionalism on the part of the dispensers, as well as the vagueness of rules and how they are applied.
References
Amir M, Feroz Z, Beg AE, Rickles N. Using a pharmacist-led mHealth to improve patient’s adherence of antidepressants: patients’ experiences in low resourceful country. BMJ Innov. 2020;29. http://dx.doi.org/10.1136/bmjinnov-2020-000422
Hafeez M. Poor Healthcare in Pakistan. Harvard International Review. 2014;35(4):52. https://www.proquest.com/docview/1652372795
Smailhodzic E, Hooijsma W, Boonstra A, Langley DJ. Social media use in healthcare: A systematic review of effects on patients and on their relationship with healthcare professionals. BMC health services research. 2016;16(1):1-14. https://doi.org/10.1186/s12913-016-1691-0
Ahmed J, Shaikh BT. An all time low budget for healthcare in Pakistan. Journal of the College of Physicians and Surgeons Pakistan. 2008;18(6):388. https://jcpsp.pk/archive/2008/Jun2008/18.pdf
Perehudoff K. Universal access to essential medicines as part of the right to health: a cross-national comparison of national laws, medicines policies, and health system indicators. Global health action. 2020;13(1):1699342. http://dx.doi.org/10.1080/16549716.2019.1699342
Organization WH. Medicines shortages: global approaches to addressing shortages of essential medicines in health systems. WHO Drug Information. 2016;30(2):180-5. https://apps.who.int/iris/handle/10665/331028
Ozawa S, Shankar R, Leopold C, Orubu S. Access to medicines through health systems in low-and middle-income countries. Oxford University Press; 2019. p. iii1-iii3. http://dx.doi.org/10.1093/heapol/czz119
Organization WH. Technical definitions of shortages and Stockouts of medicines and vaccines. Geneva: World Health Organization. 2017. https://www.who.int/publications/m/item/WHO-EMP-IAU-2017.03
Hahn SM, Date M. Report on Drug Shortages for Calendar Year 2019. Washington, DC: US Food and Drug Administration; 2020. https://fda.report/media/139613/Drug+Shortages+Report+to+Congress+for+CY+2019+%28SIGNED%29.pdf
Morris S. Medicine shortages in Australia–what are we doing about them? Australian prescriber. 2018;41(5):136. http://dx.doi.org/10.18773/austprescr.2018.047
Pharmacists ASoH-S. Drug shortages statistics. University of Utah Drug Information Service. 2018. https://www.ashp.org/drug-shortages/shortage-resources/drug-shortages-statistics?loginreturnUrl=SSOCheckOnly
Donelle J, Duffin J, Pipitone J, White-Guay B. Assessing Canada's drug shortage problem. CD Howe Institute Commentary. 2018;515. https://www.cdhowe.org/sites/default/files/attachments/research_papers/mixed/Commentary_515.pdf
Babar Z-U-D, Jamshed SQ, Malik MA, Löfgren H, Gilani A-H. The pharmaceutical industry, intellectual property rights and access to medicines in Pakistan. The new political economy of Pharmaceuticals: production, innovation and TRIPS in the global south. 2013:167-84. https://ebrary.net/72183/economics/pharmaceutical_industry_intellectual_property_rights_access_medicines_pakistan
Bukhari S, Qureshi J, Jooma R, Bile K, Kazi G, Zaibi W, et al. Essential medicines management during emergencies in Pakistan. EMHJ-Eastern Mediterranean Health Journal, 16 (Supp), 106-113, 2010. 2010. https://apps.who.int/iris/handle/10665/118030
Kaplan W, Boskovic N, Flanagan D, Lalany S, Lin C-Y, Babar Z-U-D. Pharmaceutical policy in countries with developing healthcare systems: synthesis of country case studies. Pharmaceutical Policy in Countries with Developing Healthcare Systems. 2017:405-30. http://dx.doi.org/10.1007/978-3-319-51673-8_20
Qadeer E, Fatima R, Fielding K, Qazi F, Moore D, Khan MS. Good quality locally procured drugs can be as effective as internationally quality assured drugs in treating multi-drug resistant tuberculosis. PloS one. 2015;10(4):e0126099. https://doi.org/10.1371/journal.pone.0126099
Gibson L. Drug regulators study global treaty to tackle counterfeit drugs. BMj. 2004;328(7438):486. https://doi.org/10.1136/bmj.328.7438.486-c
Ali O. Quality of ceftriaxone in Pakistan: reality and resonance. Pakistan Journal of Pharmaceutical Sciences. 2009;22(2). https://pubmed.ncbi.nlm.nih.gov/19339236/
Atif M, Ahmad M, Saleem Q, Curley L, Qamar-uz-Zaman M, Babar Z-U-D. Pharmaceutical policy in Pakistan. Pharmaceutical Policy in Countries with Developing Healthcare Systems. 2017:25-44. https://pure.hud.ac.uk/en/publications/pharmaceutical-policy-in-pakistan
Wirtz VJ, Hogerzeil HV, Gray AL, Bigdeli M, de Joncheere CP, Ewen MA, et al. Essential medicines for universal health coverage. The Lancet. 2017;389(10067):403-76. https://doi.org/10.1016/S0140-6736(16)31599-9
Nishtar S. Pakistan's deadly cocktail of substandard drugs. The Lancet. 2012;379(9821):1084-5. https://doi.org/10.1016/S0140-6736(12)60277-3
Seidle L, Khan Z, editors. Federalism and Eighteenth Amendment: Challenges and Opportunities for Transition Management in Pakistan. Islamabad: UNDP and Forum on Federations Political and Administrative Decentralization; 2012. https://forumfed.org/document/report-federalism-and-eighteenth-amendment/
Kumar S, Bano S. Comparison and analysis of health care delivery systems: Pakistan versus Bangladesh. J Hosp Med Manage. 2017;3(1):21-2. https://hospital-medical-management.imedpub.com/comparison-and-analysis-of-health-care-delivery-systems-pakistan-versus-bangladesh.pdf
Rashid H. Impact of the drug regulatory authority Pakistan: an evaluation. New Visions for Public Affairs. 2015;7:50-61. https://bpb-us-w2.wpmucdn.com/sites.udel.edu/dist/5/10069/files/2018/01/nvpa_rashid-1dtzm9j.pdf
Kharal A. Bad medicine: Over 450 pharmacies selling spurious drugs in Lahore. The Express Tribune with the International New York Times. 2013. https://tribune.com.pk/story/700743/bad-medicine-over-450-pharmacies-selling-spurious-drugs-in-lahore
Hussain A, Ibrahim M, Baber Z. Using the potentials of community pharmacies to promote rational drug use in Pakistan: An opportunity exists or lost? JPMA The Journal of the Pakistan Medical Association. 2012;62(11):1217-22. https://pubmed.ncbi.nlm.nih.gov/23866415/
Organization WH. Rational use of medicines: progress in implementing the WHO medicines strategy. EB118/6. 2006;11. https://apps.who.int/gb/ebwha/pdf_files/EB118/B118_6-en.pdf
Amin A, Khan MA, Azam SMF, Haroon U. Review of prescriber approach towards rational drug practice in hospitalised patients. Journal of Ayub Medical College Abbottabad. 2011;23(1):19-22. https://ayubmed.edu.pk/JAMC/23-1/Adnan.pdf
Muhammad N, Zaman S, Rahman S, Khan S, Ali Q. Need of clinical Pharmacist for Rationalization of Prescription. Int Res J Pharm. 2012;3(2):84-6. https://www.irjponline.com/admin/php/uploads/844_pdf.pdf
Aslam A, Khatoon S, Mehdi M, Mumtaz S, Murtaza B. Evaluation of rational drug use at teaching hospitals in Punjab, Pakistan. Journal of Pharmacy Practice and Community Medicine. 2016;2(2):54-7. https://jppcm.org/archives/sites/default/files/10.5530.jppcm_.2016.2.6.pdf
Akram MS, Qamar A, Rehman A, Bano F, Pervaiz F. The Study of Evaluation of Drug Use by Using WHO’S Prescribing, Patient Care and Health Facility Indicators in Selected Health Facilities in Province Punjab, Pakistan. Journal of Applied Pharmaceutical Science. 2012;2(9):088-92. https://japsonline.com/abstract.php?article_id=639&sts=2
Bano N, Najam R, Qazi F. Irrational drug use based on self medication for some common clinical conditions in an educated population of Karachi. 2012. https://pjms.com.pk/index.php/pjms/article/viewFile/1905/453
Zaidi S, Nishtar NA. Rational prescription & use: a snapshot of the evidence from Pakistan and emerging concerns. therapy. 2012;19:20. https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/195/
Le Grand A, Hogerzeil HV, Haaijer-Ruskamp FM. Intervention research in rational use of drugs: a review. Health policy and planning. 1999;14(2):89-102. https://doi.org/10.1093/heapol/14.2.89
Akhtar MA. Rational prescribing. Pak J Med Sci. 2009;25(4):523-5. https://www.pjms.com.pk/issues/julsep09/pdf/01.%20Editorial.pdf
Akhtar MA. Non-availability of Essential Drugs in Pakistan. Pulse International. 2013;14(24). https://doi.org/10.1371/journal.pone.0253880. eCollection 2021
Khan MU, Hassali MAA, Ahmad A, Elkalmi RM, Zaidi STR, Dhingra S. Perceptions and practices of community pharmacists towards antimicrobial stewardship in the state of Selangor, Malaysia. PloS one. 2016;11(2):e0149623. https://doi.org/10.1371/journal.pone.0149623
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 author

This work is licensed under a Creative Commons Attribution 4.0 International License.
