Theoretical medicine: the foundation of the future of medicine
DOI:
https://doi.org/10.57125/FEM.2024.06.30.05Keywords:
biomedical sciences, pathophysiology, clinical research, molecular medicine, genetic engineering, regenerative medicine, pharmacological innovations, diagnostic methods, systems biology, nanomedicineAbstract
When comparing the current capabilities of medicine in diagnosis and treatment with those of twenty years ago, one can certainly say that back then, such advancements were merely a dream. The success in diagnosis, treatment, and prevention is usually the result of knowledge synthesis accumulated over several centuries. This becomes possible due to the development of such disciplines as molecular biology, genetic engineering, systems biology, nanomedicine, and regenerative medicine. Modern technologies make it possible to manage many processes and digitisation covers more and more fields of medicine.
Aim: of the research was to carry out a literature search concerning the importance of fundamental sciences knowledge, to familiarise with some modern directions: genetic engineering, molecular biology, nanotechnology and others, to demonstrate the successful implementation of their assets in diagnostic and therapeutic measures.
Methodology: a generalisation and scientific publications analysis over the past 5 years on the topic of this study has been carried out. To search for literary sources, databases and search engines, focusing primarily on PubMed for the research topic were utilised.
Results: Following a literature analysis, undeniable confirmation that biomedical sciences—physiology, pathophysiology, pathomorphology, and microbiology—were the essential foundation without which success in treatment and diagnosis would be unattainable was discovered. The accumulation of the database opened up new promising ways of theoretical medicine. The success of molecular biology and biochemistry has become a source for the successful development of nanotechnology, genetic engineering and regenerative medicine.
Scientific Novelty: the novelty of this research is in tracking the correlation between fundamental medical and biological sciences and the development of modern areas of medicine.
Conclusion: the presented literature search demonstrated that the theoretical foundations of medicine are extremely important and allow to successfully develop modern directions of medicine and introduce them into clinical medicine.
References
Lysetskyi, B., Kobyletskyi, O., Shchybovyk, D., Zubova M., Litvin, O. Neuroplasticity in the pathogenesis and treatment of chronic pain syndrome: new research and therapeutic perspectives. Futur Med [Іnternet]. 2024;3(1): 45-58. Available from: https://doi.org/10.57125/FEM.2024.03.30.05
Tretter F, Löffler-Stastka H. Medical knowledge integration and "systems medicine": Needs, ambitions, limitations and options. Med Hypotheses. [Internet]. 2019; Dec;133:109386. Available from: https://pubmed.ncbi.nlm.nih.gov/31541780/
Gore JC. Artificial intelligence in medical imaging. Magn Reson Imaging. [Internet]. 2020; May;68:A1-A4. Available from: https://pubmed.ncbi.nlm.nih.gov/31857130/
Tai-MacArthur S, Lombardi G, Shangaris P. The Theoretical Basis of In Utero Hematopoietic Stem Cell Transplantation and Its Use in the Treatment of Blood Disorders. Stem Cells Dev. [Internet]. 2021;Jan 15;30(2):49-58. Available from: https://pubmed.ncbi.nlm.nih.gov/33280478/
Stevenson R, Samokhina E, Mangat A, Rossetti I, Purushotham SS, Malladi CS, Morley JW, Buskila Y. Astrocytic K+ clearance during disease progression in amyotrophic lateral sclerosis. Glia. [Internet]. 2023; Oct;71(10):2456-2472. Available from: https://pubmed.ncbi.nlm.nih.gov/37395323/
Tretter F, Wolkenhauer O, Meyer-Hermann M, Dietrich JW, Green S, Marcum J, Weckwerth W. The Quest for System-Theoretical Medicine in the COVID-19 Era. Front Med (Lausanne). [Internet]. 2021; Mar 29;8:640974. Available from: https://www.frontiersin.org/articles/10.3389/fmed.2021.640974/full
Krenner HJ, Westerhausen C. Handy nanoquakes. Nat Mater. [Internet]. 2022; May;21(5):499-501. Available from: https://pubmed.ncbi.nlm.nih.gov/35505228/
Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, Schmidt HHHW. Network pharmacology: curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci. [Internet]. 2022; Available from: Feb;43(2):136-150. https://pubmed.ncbi.nlm.nih.gov/34895945/
Shi M, Shen Z, Zhang N, Wang L, Yu C, Yang Z. CRISPR/Cas9 technology in disease research and therapy: a review. Sheng Wu Gong Cheng Xue Bao. [Internet]. 2021; Apr 25;37(4):1205-1228. Available from: https://pubmed.ncbi.nlm.nih.gov/33973436/
Hu H, Feng W, Qian X, Yu L, Chen Y, Li Y. Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics. Adv Mater. [Internet]. 2021; Mar;33(12):e2005062. Available from: https://pubmed.ncbi.nlm.nih.gov/33565157/
Papathomas TG, Nosé V. New and Emerging Biomarkers in Endocrine Pathology. Adv Anat Pathol. [Internet]. 2019; May;26(3):198-209. Available from: https://pubmed.ncbi.nlm.nih.gov/30730313/
Zhang B, Huang Y, Huang Y. Advances in Nanodynamic Therapy for Cancer Treatment. Nanomaterials (Basel). [Internet]. 2024; Apr 8;14(7):648. Available from: https://www.mdpi.com/2079-4991/14/7/648.
Merker L, Bautsch BW, Ebert T, Guthoff M, Isermann B. Nephropathy in Diabetes. Exp Clin Endocrinol Diabetes. [Internet]. 2021; Aug;129(S 01):S60-S63. Available from: https://pubmed.ncbi.nlm.nih.gov/33395705/
Lanigan TM, Kopera HC, Saunders TL. Principles of Genetic Engineering. Genes (Basel). [Internet]. 2020; Mar 10;11(3):291. Available from: https://pubmed.ncbi.nlm.nih.gov/32164255/
Cacheiro P, Haendel MA, Smedley D; International Mouse Phenotyping Consortium and the Monarch Initiative. New models for human disease from the International Mouse Phenotyping Consortium. Mamm Genome. [Internet]. 2019; Jun;30(5-6):143-150. Available from: https://pubmed.ncbi.nlm.nih.gov/31127358/.
Zhao K, Kang SX, Yang YY, Yu DG. Electrospun functional nanofiber membrane for antibiotic removal in water: Review. Polymers (Basel). [Internet]. 2021;13(2):226. Available from: https://www.mdpi.com/2073-4360/13/2/226
Chopra H, Mohanta YK, Mahanta S, Mohanta TK, Singh I, Avula SK, et al. Recent updates in nanotechnological advances for wound healing: A narrative review. Nanotechnol Rev [Internet]. 2023;12(1). Available from: http://dx.doi.org/10.1515/ntrev-2023-0129
Nauman S, Lubineau G, Alharbi HF. Post processing strategies for the enhancement of mechanical properties of enms (Electrospun nanofibrous membranes): A review. Membranes (Basel). [Internet]. 2021;11(1):39. 10.3390. Available from: https://www.mdpi.com/2077-0375/11/1/39.
Déjardin LM, Perry KL, von Pfeil DJF, Guiot LP. Interlocking Nails and Minimally Invasive Osteosynthesis. Vet Clin North Am Small Anim Pract. [Internet]. 2020; Jan;50(1):67-100. Available from: https://pubmed.ncbi.nlm.nih.gov/31668598/
Pandya R, Talib Z. A scoping review of regenerative medicine in medical education. BMC Med Educ. [Internet]. 2022; Nov 5;22(1):758. Available from: https://pubmed.ncbi.nlm.nih.gov/36335360/
Tretter F, Wolkenhauer O, Meyer-Hermann M, Dietrich JW, Green S, Marcum J and Weckwerth W. The Quest for System-Theoretical Medicine in the COVID-19 Era. Front. Med. [Internet]. 2021; 8:640974. Available from: https://philarchive.org/archive/TRETQF
Xiaochen R, Moyuan Z, Blake L, Mikaël MM, Ziad J. Growth Factor Engineering Strategies for Regenerative Medicine Applications. Frontiers in Bioengineering and Biotechnology. [Internet]. 2020;7. Available from: https://www.frontiersin.org/articles/10.3389/fbioe.2019.00469/full
Chandrasegaran S, Scanlan RL, Clark P, Pease L, Wordsworth J, Shanley DP. Systems Biology of Ageing. Subcell Biochem. [Internet]. 2023;102:415-424. Available from: https://pubmed.ncbi.nlm.nih.gov/36600142/
Aguas R, White L, Hupert N, Shretta R, Pan-Ngum W, Celhay O, et al. Modelling the COVID-19 pandemic in context: an international participatory approach. BMJ Global Health. [Internet]. 2020;5:e003126. Available from: https://pubmed.ncbi.nlm.nih.gov/33361188/
Lightner AL, Chan T. Precision regenerative medicine. Stem Cell Res Ther [Internet]. 2021;12(1). Available from: http://dx.doi.org/10.1186/s13287-020-02092-w
Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019;8(8):886. Available from: https://doi.org/10.3390/cells8080886
Nii T, Katayama Y. Biomaterial-Assisted Regenerative Medicine. International Journal of Molecular Sciences. 2021;22(16):8657. Available from: https://doi.org/10.3390/ijms22168657
Catoira MC, Fusaro L, Di Francesco D. Overview of natural hydrogels for regenerative medicine applications. J Mater Sci: Mater Med. 2019;30:115. Available from: https://doi.org/10.1007/s10856-019-6318-7
Basiri A, Pazhouhnia Z, Beheshtizadeh N. Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises. Stem Cell Rev and Rep. 2021;17:163–175. Available from: https://doi.org/10.1007/s12015020-09994-5
Tufan A, Avanoglu Güler A, Matucci-Cerinic M. COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med Sci. [Internet]. 2020; 50:620–32. Available from: https://pubmed.ncbi.nlm.nih.gov/32299202/
Blumenthal D, Fowler EJ, Abrams M, Collins SR. Covid-19 — implications for the health care system. N Engl J Med. [Internet]. 2020; 383:1483–8. Available from: https://www.nejm.org/doi/full/10.1056/NEJMsb2021088
Ma H, Burger C, Chu B, Hsiao BS. Electrospun nanofibers for environmental protection. Handb Fibrous Mater. [Internet]. 2020;11(10):770. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527342587.ch28
Burns TC, Quinones-Hinojosa A. Regenerative medicine for neurological diseases—will regenerative neurosurgery deliver? BMJ. [Internet]. 2021;373:n955. Available from: https://pubmed.ncbi.nlm.nih.gov/34162530/
Kerr M. The Family Movement, Bowen Theory, and Theoretical Medicine: A View from the 21st Century. Aust N Z J Fam Ther. [Internet]. 2019;40:308-318. Available from: https://doi.org/10.1002/anzf.1381
Veit W. Experimental philosophy of medicine and the concepts of health and disease. Theor Med Bioeth. 2021;42:169–186. Available from: https://doi.org/10.1007/s11017-021-09550-3
Marcum JA. Professing clinical medicine in an evolving health care network. Theor Med Bioeth. [Internet]. 2019;40:197–215. Available from: https://doi.org/10.1007/s11017-019-09492-x
Smits A, Annaert P, Cavallaro G, De Cock PAJG, de Wildt SN, Kindblom JM, Lagler FB, Moreno C, Pokorna P, Schreuder MF, Standing JF, Turner MA, Vitiello B, Zhao W, Weingberg AM, Willmann R, van den Anker J, Allegaert K. Current knowledge, challenges and innovations in developmental pharmacology: A combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper. Br J Clin Pharmacol. [Internet]. 2022 Dec;88(12):4965-4984. Available from: https://pubmed.ncbi.nlm.nih.gov/34180088/
Mehandru S, Merad M. Pathological sequelae of long-haul COVID. Nat Immunol. [Internet]. 2022 Feb;23(2):194-202. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127978/
Seo SK, van der Graaf PH. How a Pandemic Simultaneously Strengthened Existing Fundamentals and Drove New Innovations in Clinical Pharmacology. Clin Pharmacol Ther. [Internet]. 2022; Available from: https://pubmed.ncbi.nlm.nih.gov/36403083/
Lee SH et al. Depression as a mediator of chronic fatigue and post-traumatic stress symptoms in Middle East respiratory syndrome survivors. Psychiatry Invest. [Internet]. 2019; 16: 59–64 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354037/
Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry [Internet]. 2020 [cited 2024 May 11];7(7):611–27. Available from: http://dx.doi.org/10.1016/s2215-0366(20)30203-0
Magne TM, Vieira de O, Alencar LMR. Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications. J Nanostruct Chem. 2022;12:693–727. Available from: https://doi.org/10.1007/s40097-021-00444-3
Edgar L, Pu T, Porter B, Aziz JM, La Pointe C, Asthana A, Orlando G. Regenerative medicine, organ bioengineering and transplantation. Br J Surg. [Internet]. 2020; Jun.107(7):793-800. Available from: https://pubmed.ncbi.nlm.nih.gov/32463143/
Tretter F, Loffler-Stastka H. The human ecological perspective and biopsychosocial medicine. Int J Environ Res Public Health. [Internet]. 2019; 16:4230. Available from: https://www.mdpi.com/1660-4601/16/21/4230
Peirone B, Rovesti GL, Baroncelli AB, Piras LA. Minimally Invasive Plate Osteosynthesis Fracture Reduction Techniques in Small Animals. Vet Clin North Am Small Anim Pract. [Internet]. 2020; Jan;50(1):23-47. Available from: https://pubmed.ncbi.nlm.nih.gov/31635912/
Zupanic A, Bernstein HC, Heiland I. Systems biology: current status and challenges. Cell Mol Life Sci. [Internet]. 2020; Feb;77(3):379-380. Available from: https://pubmed.ncbi.nlm.nih.gov/3193285
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