The Use of Laparoscopic Technologies in the Treatment of Patients with Complicated Forms of Colon Cancer

Authors

DOI:

https://doi.org/10.57125/FEM.2025.09.30.02

Keywords:

colon cancer, complication, laparoscopy, surgery

Abstract

Aim of the study. To analyze the outcomes of using laparoscopic methods in the treatment of patients with complicated forms of malignant colon diseases.

Materials and Methods. A prospective cohort study included 109 (100 %) patients with complicated forms of colon cancer. 74 (67.89 %) patients had tumor-induced acute intestinal obstruction (AIO); 21 (19.27 %) had tumor perforation; 6 (5.50 %) had acute gastrointestinal bleeding (GIB); 3 (2.75 %) had both AIO and perforation; and 5 (4.59 %) had both AIO and bleeding.

Results. Emergency surgeries were performed in 18 (16.51 %) patients, urgent surgeries in 17 (15.60 %), and delayed surgeries in 74 (67.89 %). Laparoscopic techniques were used in 31 (28.44 %) cases. In 71 (65.13 %) patients, laparotomy was performed. Postoperative complications occurred in 6 (19.35 %) laparoscopic cases, compared to
32 (41.03 %) laparotomy cases (p = 0.0286). Wound complications (seromas, hematomas, infiltrates, infections, dehiscence) were more frequent in the laparotomy group —
17 (21.79 %) vs. 1 (3.23 %) in the laparoscopic group (p = 0.0083). Mortality was
5 (16.13 %) in the laparoscopic group and 18 (23.08 %) in the laparotomy group
(p = 0.3781). Average hospital stay: 10.00 (8.00; 13.00) days for laparoscopy vs.
19.00 (13.00; 27.00) days for laparotomy (p = 0.0011).

Conclusions. Laparoscopic surgery methods can be applied in treating all types of complicated colon cancer. This type of surgery reduces postoperative complications and hospital stay in research group.

References

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. https://doi.org/10.3322/caac.21660

Sharma R, Abbasi-Kangevari M, Abd-Rabu R, Abidi H, Abu-Gharbieh E, Acuna JM, Adhikari S, Advani SM, Afzal MS, Aghaie Meybodi M, Ahinkorah BO, Ahmad S, Ahmadi A, Ahmadi S, Ahmed H, Ahmed LA, Ahmed MB, Al Hamad H, Alahdab F, Alanezi FM, Alanzi TM, Alhalaiqa FA, Alimohamadi Y, Alipour V, Aljunid SM, Alkhayyat M, Almustanyir S, Al-Raddadi RM, Alvand S, Alvis-Guzman N, Amini S, Ancuceanu R, Anoushiravani A, Anoushirvani AA, Ansari-Moghaddam A, Arabloo J, Aryannejad A, Asghari Jafarabadi M, Athari SS, Ausloos F, Ausloos M, Awedew AF, Awoke MA, Ayana TM, Azadnajafabad S, Azami H, Azangou-Khyavy M, Azari Jafari A, Badiye AD, Zoladl M. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Amp Hepatol [Internet]. Apr. 2022 [Cite 30 Jul. 2025]. Available on: https://doi.org/10.1016/s2468-1253(22)00044-9

Fedorenko ZP, Hulak LO, Mykhaylovych YUY. Rak v Ukrayini, 2018 – 2019. Zakhvoryuvanistʹ, smertnistʹ, pokaznyky diyalʹnosti onkolohichnoyi sluzhby. Byuletenʹ natsionalʹnoho kantser-reyestru Ukrayiny [Internet]. Oct. 2020 [Cite 30 Jul. 2025];21. Available on: http://www.ncru.inf.ua/publications/BULL_21/index.htm

Gutierrez CS, Passos SC, Castro SM, Okabayashi LS, Berto ML, Lorenzen MB, Caumo W, Stefani LC. Few and feasible preoperative variables can identify high-risk surgical patients: derivation and validation of the Ex-Care risk model. Br J Anaesth. Oct. 2020;126:525-32. https://doi.org/10.1016/j.bja.2020.09.036

GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study. Lancet. 2020;396:1204-22. https://doi.org/10.1016/S2468-1253(22)00044-9

Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Weichert W. Morphology matters. American Journal of Surgical Pathology. 2021;45(7):969-78. https://doi.org/10.1097/pas.0000000000001692

Bielikova IV, Khorosh MV, Radchenko NR, Lyakhova NA. STATE OF ORGANIZATION OF PROVIDING ONCOLOGICAL MEDICAL CARE TO THE POPULATION OF UKRAINE. Pol Merkur Lekarski. 2023;51(6):638-645. https://doi.org/10.36740/Merkur202306110

Biondo S, Gálvez A, Ramírez E, Frago R, Kreisler E. Emergency surgery for obstructing and perforated colon cancer: patterns of recurrence and prognostic factors. Tech Coloproctol. 2019 Dec;23(12):1141-1161. https://doi.org/10.1007/s10151-019-02110-x

Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Farkas L, Garrido-Laguna I, Grem JL, Gunn A, Hecht JR, Hoffe S, Hubbard J, Hunt S, Johung KL, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Gurski LA. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 Mar 2;19(3):329-359. https://doi.org/10.6004/jnccn.2021.0012

Pavlidis ET, Galanis IN, Pavlidis TE. Management of obstructed colorectal carcinoma in an emergency setting: An update. World J Gastrointest Oncol. 2024 Mar 15;16(3):598-613. https://doi.org/10.4251/wjgo.v16.i3.598

Itonaga S, Hamada S, Ihara E, Honma H, Fukuya H, Ookubo A, Sasaki T, Yoshimura D, Nakamuta M, Sumida Y, Harada N. Importance of preoperative total colonoscopy and endoscopic resection after self-expandable metallic stent placement for obstructive colorectal cancer as a bridge-to-surgery. BMC Gastroenterol. 2023 Jul 24;23(1):251. https://doi.org/10.1186/s12876-023-02888-z

Spannenburg L, Sanchez Gonzalez M, Brooks A, Wei S, Li X, Liang X, Gao W, Wang H. Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials. Eur J Surg Oncol. 2020 Aug;46(8):1404-1414. https://doi.org/10.1016/j.ejso.2020.04.052

Balciscueta I, Balciscueta Z, Uribe N, García-Granero E. Perineural invasion is increased in patients receiving colonic stenting as a bridge to surgery: a systematic review and meta-analysis. Tech Coloproctol. 2021 Feb;25(2):167-176. https://doi.org/10.1007/s10151-020-02350-2

Russo S, Conigliaro R, Coppini F, Dell'Aquila E, Grande G, Pigò F, Mangiafico S, Lupo M, Marocchi M, Bertani H, Cocca S. Acute left-sided malignant colonic obstruction: Is there a role for endoscopic stenting? World J Clin Oncol. 2023 May 24;14(5):190-197. https://doi.org/10.5306/wjco.v14.i5.190

Vogel JD, Felder SI, Bhama AR, Hawkins AT, Langenfeld SJ, Shaffer VO, Thorsen AJ, Weiser MR, Chang GJ, Lightner AL, Feingold DL, Paquette IM. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer. Dis Colon Rectum. 2022 Feb 1;65(2):148-177. https://doi.org/10.1097/DCR.0000000000002323

Argilés G, Tabernero J, Labianca R, Hochhauser D, Salazar R, Iveson T, Laurent-Puig P, Quirke P, Yoshino T, Taieb J, Martinelli E, Arnold D; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020 Oct;31(10):1291-1305. https://doi.org/10.1016/j.annonc.2020.06.022

Kubrak MA, Zavgorodniy SM, Danylyuk MB, Chemerys YuO. A comprehensive individualized approach to the treatment of patients with acute intestinal obstruction of tumor origin. Ukrainian Journal of Clinical Surgery. 2025;92(1):27-30. https://doi.org/10.26779/2786-832X.2025.1.27

van Hooft JE, Veld JV, Arnold D, Beets-Tan RGH, Everett S, Götz M, van Halsema EE, Hill J, Manes G, Meisner S, Rodrigues-Pinto E, Sabbagh C, Vandervoort J, Tanis PJ, Vanbiervliet G, Arezzo A. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020. Endoscopy. 2020 May;52(5):389-407. https://doi.org/10.1055/a-1140-3017

Otani K, Kawai K, Hata K, Tanaka T, Nishikawa T, Sasaki K, Kaneko M, Murono K, Emoto S, Nozawa H. Colon cancer with perforation. Surg Today. 2019 Jan;49(1):15-20. https://doi.org/10.1007/s00595-018-1661-8

Gosavi R, Chia C, Michael M, Heriot AG, Warrier SK, Kong JC. Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis. Int J Colorectal Dis. 2021 Oct;36(10):2063-2070. https://doi.org/10.1007/s00384-021-03945-3

Aliseda D, Arredondo J, Sánchez-Justicia C, Alvarellos A, Rodríguez J, Matos I, Rotellar F, Baixauli J, Pastor C. Survival and safety after neoadjuvant chemotherapy or upfront surgery for locally advanced colon cancer: meta-analysis. Br J Surg. 2024 Jan 31;111(2):znae021. https://doi.org/10.1093/bjs/znae021

Huijts DD, Dekker JWT, van Bodegom-Vos L, van Groningen JT, Bastiaannet E, Marang-van de Mheen PJ. Differences in organization of care are associated with mortality, severe complication and failure to rescue in emergency colon cancer surgery. Int J Qual Health Care. 2021 Mar 11;33(1):mzab038. doi: 10.1093/intqhc/mzab038

Degett TH, Dalton SO, Christensen J, Søgaard J, Iversen LH, Gögenur I. Mortality after emergency treatment of colorectal cancer and associated risk factors-a nationwide cohort study. Int J Colorectal Dis. 2019 Jan;34(1):85-95. https://doi.org/10.1007/s00384-018-3172-x.

Seo SY, Kim SW. Endoscopic Management of Malignant Colonic Obstruction. Clin Endosc. 2020 Jan;53(1):9-17. https://doi.org/10.5946/ce.2019.051

Lygre KB, Eide GE, Forsmo HM, Dicko A, Storli KE, Pfeffer F. Complications after open and laparoscopic right-sided colectomy with central lymphadenectomy for colon cancer: randomized controlled trial. BJS Open. 2023 Jul 10;7(4):zrad074. https://doi.org/10.1093/bjsopen/zrad074

Li YS, Meng FC, Lin JK. Procedural and post-operative complications associated with laparoscopic versus open abdominal surgery for right-sided colonic cancer resection: A systematic review and meta-analysis. Medicine (Baltimore). 2020 Oct 2;99(40):e22431. https://doi.org/10.1097/MD.0000000000022431

Podda M, Pisanu A, Morello A, Segalini E, Jayant K, Gallo G, Sartelli M, Coccolini F, Catena F, Di Saverio S. Laparoscopic versus open colectomy for locally advanced T4 colonic cancer: meta-analysis of clinical and oncological outcomes. Br J Surg. 2022 Mar 15;109(4):319-331. https://doi.org/10.1093/bjs/znab464

Downloads

Published

2025-08-27

How to Cite

Kubrak, M., Zavgorodnii, S., & Danilyk, M. (2025). The Use of Laparoscopic Technologies in the Treatment of Patients with Complicated Forms of Colon Cancer. Futurity Medicine, 4(3). https://doi.org/10.57125/FEM.2025.09.30.02