Vaccination of pregnant women against COVID-19 under martial law: a narrative review
DOI:
https://doi.org/10.57125/FEM.2022.06.30.01Keywords:
Vaccination, coronavirus, COVID-19, pregnant women, Neonatal outcomesAbstract
Background: Global vaccination programs against the coronavirus illness of 2019 (COVID-19) have been established as the primary measure to minimise and control the effects of the COVID-19 pandemic. During pregnancy, it is assumed that the expectant mother and her fetus are both in danger from the possibility of a viral infection.
Aim: to evaluate the safety and effectiveness of vaccination against COVID-19 for pregnant women and determine the impact of vaccination on pregnancy outcomes.
Methods: In this review, English studies from common databases such as Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library with the keywords "Vaccination," "pregnancy," and "pregnant women," combined with keywords, involving "COVID-19," were involved. The end date for this review is March 2022.
Scientific novelty: The main objective of this paper is to evaluate the effect of vaccination of pregnant women against COVID-19. Even though many studies assessed the efficacy of vaccination against COVID-19, most failed to determine the safety and effectiveness of COVID-19 vaccination for immunocompromised patients, especially pregnant women. Additionally, the impact of COVID-19 vaccination on neonatal outcomes was evaluated.
The practical significance of the obtained result: Concerns have also been raised about potential risks associated with vaccination during pregnancy or breastfeeding. Given these uncertainties, it is important for healthcare providers to carefully consider the risks and benefits of COVID-19 vaccination for pregnant women and their babies. Further research is needed to better understand the effects of vaccination on perinatal outcomes and to inform clinical decision-making around vaccine use in this population.
Conclusion: The COVID-19 vaccination is a safe and effective way to protect pregnant women from the virus. The benefits of getting vaccinated outweigh the risks, as pregnant women are at an increased risk of severe illness and complications from COVID-19. The Centers for Disease Control and Prevention (CDC) recommends that pregnant women get vaccinated, and many healthcare providers also recommend it. However, it is important for pregnant women to discuss their individual situation with their healthcare provider before making a decision about vaccination. Overall, getting vaccinated can help to protect both the mother and her unborn child from COVID-19.
Background: Global vaccination programs against the coronavirus illness of 2019 (COVID-19) have been established as the primary measure to minimise and control the effects of the COVID-19 pandemic. During pregnancy, it is assumed that the expectant mother and her fetus are both in danger from the possibility of a viral infection.
Aim: to evaluate the safety and effectiveness of vaccination against COVID-19 for pregnant women and determine the impact of vaccination on pregnancy outcomes.
Methods: In this review, English studies from common databases such as Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library with the keywords "Vaccination," "pregnancy," and "pregnant women," combined with keywords, involving "COVID-19," were involved. The end date for this review is March 2022.
Scientific novelty: The main objective of this paper is to evaluate the effect of vaccination of pregnant women against COVID-19. Even though many studies assessed the efficacy of vaccination against COVID-19, most failed to determine the safety and effectiveness of COVID-19 vaccination for immunocompromised patients, especially pregnant women. Additionally, the impact of COVID-19 vaccination on neonatal outcomes was evaluated.
The practical significance of the obtained result: Concerns have also been raised about potential risks associated with vaccination during pregnancy or breastfeeding. Given these uncertainties, it is important for healthcare providers to carefully consider the risks and benefits of COVID-19 vaccination for pregnant women and their babies. Further research is needed to better understand the effects of vaccination on perinatal outcomes and to inform clinical decision-making around vaccine use in this population.
Conclusion: The COVID-19 vaccination is a safe and effective way to protect pregnant women from the virus. The benefits of getting vaccinated outweigh the risks, as pregnant women are at an increased risk of severe illness and complications from COVID-19. The Centers for Disease Control and Prevention (CDC) recommends that pregnant women get vaccinated, and many healthcare providers also recommend it. However, it is important for pregnant women to discuss their individual situation with their healthcare provider before making a decision about vaccination. Overall, getting vaccinated can help to protect both the mother and her unborn child from COVID-19.
References
Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med [Internet]. 2020;288(2):192–206. Available from: http://dx.doi.org/10.1111/joim.13091
Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res [Internet]. 2020;24:91–8. Available from: https://www.sciencedirect.com/science/article/pii/S2090123220300540
Ramachandran V, Esaki M S, Vijayakumar V, Sadras Panchatcharam T. Is herd immunity against SARS-CoV-2 a silver lining? Front Immunol [Internet]. 2020;11:586781. Available from: http://dx.doi.org/10.3389/fimmu.2020.586781
Randolph HE, Barreiro LB. Herd immunity: Understanding COVID-19. Immunity [Internet]. 2020;52(5):737–41. Available from: http://dx.doi.org/10.1016/j.immuni.2020.04.012
Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ [Internet]. 2020;370:m3320. Available from: http://dx.doi.org/10.1136/bmj.m3320
Collier A-RY, McMahan K, Yu J, Tostanoski LH, Aguayo R, Ansel J, et al. Immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women. JAMA [Internet]. 2021;325(23):2370–80. Available from: http://dx.doi.org/10.1001/jama.2021.7563
Afshar Y, Gaw SL, Flaherman VJ, Chambers BD, Krakow D, Berghella V, et al. Clinical presentation of Coronavirus disease 2019 (COVID-19) in pregnant and recently pregnant people. Obstet Gynecol [Internet]. 2020;136(6):1117–25. Available from: http://dx.doi.org/10.1097/AOG.0000000000004178
CDC. Pregnant and recently pregnant people [Internet]. Centers for Disease Control and Prevention. 2022 [cited 2022 Apr 10]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/pregnant-people.html
COVID-19 and pregnancy: What maternal-fetal medicine subspecialists need to know [Internet]. Amazonaws.com. [cited 2022 Apr 10]. Available from: https://s3.amazonaws.com/cdn.smfm.org/media/3559/COVID19-What_MFMs_need_to_know_%286-21-22%29_final.pdf
Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG [Internet]. 2020;127(11):1374–80. Available from: http://dx.doi.org/10.1111/1471-0528.16339
World Health Organization. Coronavirus disease 2019 (COVID-19): situation report, 41. 2020 [cited 2021 Apr 10]; Available from: https://apps.who.int/iris/handle/10665/331352
Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature [Internet]. 2020;579(7798):270–3. Available from: http://dx.doi.org/10.1038/s41586-020-2012-7
Sturgeon Delia C. Technologies employed within the healthcare setting during the COVID-19 pandemic for A continuation of care: Emerging CoP. MCAST Journal of Applied Research & Practice [Internet]. 2021;5(1):212–32. Available from: http://dx.doi.org/10.5604/01.3001.0015.0199
Bai Y, Yao L, Wei T, Tian F, Jin D-Y, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA [Internet]. 2020;323(14):1406–7. Available from: http://dx.doi.org/10.1001/jama.2020.2565
Stokes EK, Zambrano LD, Anderson KN, Marder EP, Raz KM, El Burai Felix S, et al. Coronavirus disease 2019 case surveillance - United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep [Internet]. 2020;69(24):759–65. Available from: http://dx.doi.org/10.15585/mmwr.mm6924e2
Wang C, Sun S, Ding X. The therapeutic effects of traditional chinese medicine on COVID-19: a narrative review. Int J Clin Pharm [Internet]. 2021;43(1):35–45. Available from: http://dx.doi.org/10.1007/s11096-020-01153-7
Douedi S, Miskoff J. Novel coronavirus 2019 (COVID-19): A case report and review of treatments. Medicine (Baltimore) [Internet]. 2020;99(19):e20207. Available from: http://dx.doi.org/10.1097/MD.0000000000020207
Stumpfe FM, Titzmann A, Schneider MO, Stelzl P, Kehl S, Fasching PA, et al. SARS-CoV-2 infection in pregnancy - a review of the current literature and possible impact on maternal and neonatal outcome. Geburtshilfe Frauenheilkd [Internet]. 2020;80(4):380–90. Available from: http://dx.doi.org/10.1055/a-1134-5951
Asadi L, Tabatabaei RS, Safinejad H, Mohammadi M. New corona virus (COVID-19) management in pregnancy and childbirth. Arch Clin Infect Dis [Internet]. 2020;15(COVID-19). Available from: http://dx.doi.org/10.5812/archcid.102938
Nasir U, Ahmad S. Management and perspective of Coronavirus disease 2019 (COVID-19), pregnancy, and hypercoagulability. SN Compr Clin Med [Internet]. 2021;3(5):1081–4. Available from: http://dx.doi.org/10.1007/s42399-021-00854-y
Narang K, Enninga EAL, Gunaratne MDSK, Ibirogba ER, Trad ATA, Elrefaei A, et al. SARS-CoV-2 infection and COVID-19 during pregnancy: A multidisciplinary review. Mayo Clin Proc [Internet]. 2020;95(8):1750–65. Available from: http://dx.doi.org/10.1016/j.mayocp.2020.05.011
Liu H, Wang L-L, Zhao S-J, Kwak-Kim J, Mor G, Liao A-H. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. J Reprod Immunol [Internet]. 2020;139(103122):103122. Available from: http://dx.doi.org/10.1016/j.jri.2020.103122
Cavalcante MB, Cavalcante CT de MB, Braga ACS, Andrade DA, Montenegro MA, Santos PAN, et al. COVID-19 treatment: Drug safety prior to conception and during pregnancy and breastfeeding. Geburtshilfe Frauenheilkd [Internet]. 2021;81(1):46–60. Available from: http://dx.doi.org/10.1055/a-1247-5271
Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol [Internet]. 2020;37(8):861–5. Available from: http://dx.doi.org/10.1055/s-0040-1710050
Perak AM, Lancki N, Kuang A, Labarthe DR, Allen NB, Shah SH, et al. Associations of maternal cardiovascular health in pregnancy with offspring cardiovascular health in early adolescence. Obstet Gynecol Surv [Internet]. 2021;76(7):385–6. Available from: http://dx.doi.org/10.1097/ogx.0000000000000947
Millard LAC, Lawlor DA, Fraser A, Howe LD. Physical activity during pregnancy and offspring cardiovascular risk factors: findings from a prospective cohort study. BMJ Open [Internet]. 2013;3(9):e003574. Available from: http://dx.doi.org/10.1136/bmjopen-2013-003574
Qu G, Chen J, Huang G, Zhang M, Yu H, Zhu H, et al. A quantitative exploration of symptoms in COVID-19 patients: an observational cohort study. Int J Med Sci [Internet]. 2021;18(4):1082–95. Available from: http://dx.doi.org/10.7150/ijms.53596
Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V, Chauhan SP. Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by severe acute respiratory syndrome Coronavirus 2 (SARS-co-V-2) infection: A systematic review: A systematic review. Obstet Gynecol [Internet]. 2020;136(2):303–12. Available from: http://dx.doi.org/10.1097/AOG.0000000000004010
Hapshy V, Aziz D, Kahar P, Khanna D, Johnson KE, Parmar MS. COVID-19 and pregnancy: Risk, symptoms, diagnosis, and treatment. SN Compr Clin Med [Internet]. 2021;3(7):1477–83. Available from: http://dx.doi.org/10.1007/s42399-021-00915-2
Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ [Internet]. 2021;193(16):E540–8. Available from: http://dx.doi.org/10.1503/cmaj.202604
Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J-C, Turner AJ, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th anniversary of the discovery of ACE2: Celebrating the 20th anniversary of the discovery of ACE2. Circ Res [Internet]. 2020;126(10):1456–74. Available from: http://dx.doi.org/10.1161/CIRCRESAHA.120.317015
Chen R, Zhang Y, Huang L, Cheng B-H, Xia Z-Y, Meng Q-T. Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Can J Anaesth [Internet]. 2020;67(6):655–63. Available from: http://dx.doi.org/10.1007/s12630-020-01630-7
Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol [Internet]. 2020;56(1):15–27. Available from: http://dx.doi.org/10.1002/uog.22088
Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA [Internet]. 2020;323(18):1846–8. Available from: http://dx.doi.org/10.1001/jama.2020.4621
Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, Arian SE, et al. Maternal death due to COVID-19. Am J Obstet Gynecol [Internet]. 2020;223(1):109.e1-109.e16. Available from: http://dx.doi.org/10.1016/j.ajog.2020.04.030
Heidary Z, Gargari OK, Fathi H, Zaki-Dizaji M, Ghaemi M, Rashidi BH. Maternal and neonatal complications, outcomes and possibility of vertical transmission in iranian women with COVID-19. Archives of Iranian Medicine. 2021.
Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of Coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis. Obstet Anesth Dig [Internet]. 2021;41(2):81–2. Available from: http://dx.doi.org/10.1097/01.aoa.0000744128.44930.48
Wenner Moyer M. The COVID generation: how is the pandemic affecting kids’ brains? Nature [Internet]. 2022 [cited 2022 Apr 10];601(7892):180–3. Available from: https://www.nature.com/articles/d41586-022-00027-4
Huang Q, Zeng J, Yan J. COVID-19 mRNA vaccines. J Genet Genomics [Internet]. 2021;48(2):107–14. Available from: http://dx.doi.org/10.1016/j.jgg.2021.02.006
Park JW, Lagniton PNP, Liu Y, Xu R-H. mRNA vaccines for COVID-19: what, why and how. Int J Biol Sci [Internet]. 2021;17(6):1446–60. Available from: http://dx.doi.org/10.7150/ijbs.59233
Tabynov K, Turebekov N, Babayeva M, Fomin G, Yerubayev T, Yespolov T, et al. An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission. NPJ Vaccines [Internet]. 2022;7(1):24. Available from: http://dx.doi.org/10.1038/s41541-022-00450-8
Heidary M, Kaviar VH, Shirani M, Ghanavati R, Motahar M, Sholeh M, et al. A comprehensive review of the protein subunit vaccines against COVID-19. Front Microbiol [Internet]. 2022;13:927306. Available from: http://dx.doi.org/10.3389/fmicb.2022.927306
Shinde V, Bhikha S, Hoosain Z, Archary M, Bhorat Q, Fairlie L, et al. Efficacy of NVX-CoV2373 covid-19 vaccine against the B.1.351 variant. N Engl J Med [Internet]. 2021;384(20):1899–909. Available from: http://dx.doi.org/10.1056/nejmoa2103055
Atyeo C, DeRiso EA, Davis C, Bordt EA, De Guzman RM, Shook LL, et al. COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women. Sci Transl Med [Internet]. 2021;13(617):eabi8631. Available from: http://dx.doi.org/10.1126/scitranslmed.abi8631
Bookstein Peretz S, Regev N, Novick L, Nachshol M, Goffer E, Ben-David A, et al. Short-term outcome of pregnant women vaccinated with BNT162b2 mRNA COVID-19 vaccine. Ultrasound Obstet Gynecol [Internet]. 2021;58(3):450–6. Available from: http://dx.doi.org/10.1002/uog.23729
Prabhu M, Murphy EA, Sukhu AC, Yee J, Singh S, Eng D, et al. Antibody response to Coronavirus disease 2019 (COVID-19) messenger RNA vaccination in pregnant women and transplacental passage into cord blood. Obstet Gynecol [Internet]. 2021;138(2):278–80. Available from: http://dx.doi.org/10.1097/AOG.0000000000004438
Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S, et al. Association of BNT162b2 COVID-19 vaccination during pregnancy with neonatal and early infant outcomes. JAMA Pediatr [Internet]. 2022;176(5):470–7. Available from: http://dx.doi.org/10.1001/jamapediatrics.2022.0001
Theiler RN, Wick M, Mehta R, Weaver A, Virk A, Swift M. Pregnancy and birth outcomes after SARS-CoV-2 vaccination in pregnancy [Internet]. bioRxiv. 2021. Available from: http://dx.doi.org/10.1101/2021.05.17.21257337
Kharbanda EO, Haapala J, DeSilva M, Vazquez-Benitez G, Vesco KK, Naleway AL, et al. Spontaneous abortion following COVID-19 vaccination during pregnancy. Obstet Anesth Dig [Internet]. 2022;42(3):133–133. Available from: http://dx.doi.org/10.1097/01.aoa.0000853568.57480.c7
Ben-Mayor Bashi T, Amikam U, Ashwal E, Hershkovitz G, Attali E, Berkovitz-Shperling R, et al. The association of maternal SARS-CoV-2 vaccination-to-delivery interval and the levels of maternal and cord blood antibodies. Int J Gynaecol Obstet [Internet]. 2022;156(3):436–43. Available from: http://dx.doi.org/10.1002/ijgo.14014
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