Comparison of the Safety Effects of Antiplatelets on the Kidneys in Patients with Vascular Disease
DOI:
https://doi.org/10.57125/FEM.2024.06.30.02Keywords:
antiplatelet, clopidogrel, acetylsalicylic acid, renal impairment, risk adverse eventAbstract
Aims: Most vascular disorders fall under the category of inflammatory diseases because they gradually harm blood vessels, disrupting the normal flow of blood to and from vital organs. The purpose of this research was to determine the potential dangers to kidney health associated with acetylsalicylic acid and clopidogrel treatment in patients with vascular diseases.
Methodology: A cross-sectional research design was employed in the study, as well as retrospective data collection methods on medical records, and purposive sampling-based data sampling methodologies.
Results: The study's findings indicated that there was no significant correlation between the use of antiplatelets and the risk of developing kidney disorders. It is rather, a patient's lifestyle, use of medications that increase the risk of renal GFR, and co-occurring diseases that may impair blood flow in the renal afferen can all increase their risk of developing a renal disorder with p-value <0.05. Nevertheless, the prolonged use of medication also plays a significant role in kidney function. The study's results indicate that renal problems are not attributed to the usage of antiplatelet drugs such as clopidogrel and acetylsalicylic acid.
Scientific Novelty: Several using antiplatelet for indicated cardiovascular disease such us, atherosclerosis, plaque formation, endothelial dysfunction, and blockage or damage to the vascular endotelial matrix are all symptoms of vascular disease, a progressive inflammatory illness, it's frequently associated with the risk of kidney disorders. The use of antiplatelet will enlarge the afferent blood vessels.
Conclusion: Instead, factors such as a patient's lifestyle, the severity of their condition, and their medical history could have a more significant impact on the likelihood of developing kidney dysfunction.
References
Liu S, Chen Z, Han L, Dong W, Li H, Koplan J, et al. Integrated multisectoral non-communicable disease prevention and control in China: A review of agencies and policies. J Glob Health [Internet]. 2020;10(2). Available from: http://dx.doi.org/10.7189/jogh.10.020304
Marchewka Z, Szymczak A, Knysz B. Comorbidities as risk factors of chronic kidney disease in HIV-infected persons. Postepy Hig I Med Doswiadczalnej [Internet]. 2015 Dec 16 [cited 2024 Apr 15];69:1364-70. Available from: https://doi.org/10.5604/17322693.1186343
Sudayasa IP, Rahman MF, Eso A, Jamaluddin J, Parawansah P, Alifariki LO, et al. Deteksi Dini Faktor Risiko Penyakit Tidak Menular Pada Masyarakat Desa Andepali Kecamatan Sampara Kabupaten Konawe. jceh [Internet]. 2020 Mar. 1 [cited 2024 Apr. 15];3(1):60-6. Available from: https://jceh.org/index.php/JCEH/article/view/37
Lu C-H, Fang C-W, Chen H-M, Fang Y-P, Fang C-T, Huang Y-B, et al. Prescribing patterns of coronary artery aneurysm in Taiwan. BMC Cardiovasc Disord [Internet]. 2019;19(1):188. Available from: http://dx.doi.org/10.1186/s12872-019-1172-6
Schrottmaier WC, Mussbacher M, Salzmann M, Assinger A. Platelet-leukocyte interplay during vascular disease. Atherosclerosis [Internet]. 2020;307:109–20. Available from: http://dx.doi.org/10.1016/j.atherosclerosis.2020.04.018
Shi J, Yang Y, Cheng A, Xu G, He F. Metabolism of vascular smooth muscle cells in vascular diseases. Am J Physiol Heart Circ Physiol [Internet]. 2020;319(3):H613–31. Available from: http://dx.doi.org/10.1152/ajpheart.00220.2020
Mondelo García C, Martínez Roca C, Rueda Núñez F, Martín Herranz MI. ¿Cuál es la dosis óptima de clopidogrel en pacientes pediátricos? An Pediatr (Barc) [Internet]. 2019;90(4):219–23. Available from: http://dx.doi.org/10.1016/j.anpedi.2018.05.020
Chiolero A, Burnier M, Maillard MP. Cardiovascular hazard of selective COX-2 inhibitors: myth or reality? Expert Opin Drug Saf [Internet]. 2002;1(1):45–52. Available from: http://dx.doi.org/10.1517/14740338.1.1.45
D.A Ningrum V, Sufiyah S, Dyah Widyastuti I, Sufriyanto Yusuf B, Dullah W. Bleeding Incidence in Patients Administered with Warfarin at Secondary Hospitals in Yogyakarta Province. Indonesian J Pharm [Internet]. 2020Sep.30 [cited 2024Apr.15];31(3):217-28. Available from: https://jurnal.ugm.ac.id/v3/IJP/article/view/814
Peres G, Mariana M, Cairrão E. Pre-eclampsia and eclampsia: An update on the pharmacological treatment applied in Portugal. J Cardiovasc Dev Dis [Internet]. 2018;5(1):3. Available from: http://dx.doi.org/10.3390/jcdd5010003
Khan H, Kanny O, Syed MH, Qadura M. Aspirin resistance in vascular disease: A review highlighting the critical need for improved point-of-care testing and personalized therapy. Int J Mol Sci [Internet]. 2022;23(19). Available from: http://dx.doi.org/10.3390/ijms231911317
Zheng Z, Ma T, Lian X, Gao J, Wang W, Weng W, et al. Clopidogrel reduces fibronectin accumulation and improves diabetes-induced renal fibrosis. Int J Biol Sci [Internet]. 2019;15(1):239–52. Available from: http://dx.doi.org/10.7150/ijbs.29063
Højlund M, Lund LC, Herping JLE, Haastrup MB, Damkier P, Henriksen DP. Second-generation antipsychotics and the risk of chronic kidney disease: a population-based case-control study. BMJ Open [Internet]. 2020;10(8):e038247. Available from: http://dx.doi.org/10.1136/bmjopen-2020-038247
Katsuno T, Togo K, Ebata N, Fujii K, Yonemoto N, Abraham L, et al. Burden of renal events associated with nonsteroidal anti-inflammatory drugs in patients with osteoarthritis and chronic low back pain: A retrospective database study. Pain Ther [Internet]. 2021;10(1):443–55. Available from: http://dx.doi.org/10.1007/s40122-020-00233-w
Luo P-J, Lin X-H, Lin C-C, Luo J-C, Hu H-Y, Ting P-H, et al. Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study. J Formos Med Assoc [Internet]. 2019;118(5):939–44. Available from: http://dx.doi.org/10.1016/j.jfma.2018.10.007
Semakula JR, Mouton JP, Jorgensen A, Hutchinson C, Allie S, Semakula L, et al. A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa. PLoS One [Internet]. 2020;15(1):e0227458. Available from: http://dx.doi.org/10.1371/journal.pone.0227458
Roberge S. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis [Internet]. Vol. 216, American Journal of Obstetrics and Gynecology. 2017. p. 110–20. Available from: https://api.elsevier.com/content/article/eid/1-s2.0-S0002937816307839
Kamri AM, Ikawati Z, Hashim R, Rahmawati F. An evaluation of the relationship between the occurrence of chronic kidney disease and the use of NSAIDs. Bali Med J. 2023;12(1):153-7. Available from: https://doi.org/10.15562/bmj.v12i1.3814
Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol [Internet]. 2018;218(3):287-293.e1. Available from: http://dx.doi.org/10.1016/j.ajog.2017.11.561
Katzung BG, Masters SB, Trevor AJ. Farmakologi Dasar & Klinik. Vol. 2. Edisi 12. Jakarta: Penerbit Buku Kedokteran EGC; 2014. Available from: https://laser.umm.ac.id/catalog-detail-copy/160002327/
Ikeme JC, Pergola PE, Scherzer R, Shlipak MG, Benavente OR, Peralta CA. Post hoc analyses of randomized clinical trial for the effect of clopidogrel added to aspirin on kidney function. Clin J Am Soc Nephrol [Internet]. 2017;12(7):1040–7. Available from: http://dx.doi.org/10.2215/cjn.00100117
Kitchens BP, Snyder RJ, Cuffy CA. A Literature Review of Pharmacological Agents to Improve Venous Leg Ulcer Healing. Wounds. 2020 Jul;32(7):195-207. PMID: 33166265.
Eikelboom JW, Hirsh J, Spencer FA, Baglin TP, Weitz JI. Antiplatelet drugs. Chest [Internet]. 2012;141(2):e89S-e119S. Available from: http://dx.doi.org/10.1378/chest.11-2293
LeFevre ML. Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med [Internet]. 2014;161(11):819–26. Available from: https://api.elsevier.com/content/abstract/scopus_id/84919499487
Xu L, Li C, Zhao L, Zhou B, Luo C, Man X, et al. Acute kidney injury after nephrectomy: a new nomogram to predict postoperative renal function. BMC Nephrol [Internet]. 2020;21(1):181. Available from: http://dx.doi.org/10.1186/s12882-020-01839-0
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
